LY 345899

CAS No. 10538-99-5

LY 345899 ( —— )

Catalog No. M22500 CAS No. 10538-99-5

LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 336 In Stock
10MG 500 In Stock
25MG 804 In Stock
50MG 1098 In Stock
100MG 1467 In Stock
500MG 2952 In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    LY 345899
  • Note
    Research use only, not for human use.
  • Brief Description
    LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
  • Description
    LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MTHFD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    10538-99-5
  • Formula Weight
    471.42
  • Molecular Formula
    C20H21N7O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (265.16 mM; Need ultrasonic)
  • SMILES
    Nc1nc(=O)c2N3C(CN(C3=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.
molnova catalog
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