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LY 345899
CAS No. 10538-99-5
LY 345899( —— )
Catalog No. M22500 CAS No. 10538-99-5
LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 336 | In Stock |
|
| 10MG | 500 | In Stock |
|
| 25MG | 804 | In Stock |
|
| 50MG | 1098 | In Stock |
|
| 100MG | 1467 | In Stock |
|
| 500MG | 2952 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameLY 345899
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NoteResearch use only, not for human use.
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Brief DescriptionLY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
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DescriptionLY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
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In VitroLY 345899 could suppress the MTHFD enzyme in the cytoplasm and mitochondria.LY 345899 could disturb the NADPH and redox homeostases and accelerate cell death under oxidative stress, such as hypoxia, or causing in vitro anchorage independence and in vivo impaired tumor growth and metastasis.
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In VivoLY345899 (Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks) shows potent antitumor activity and displays therapeutic activity against CRC in vivo. Animal Model:SW620 or PDX-based BABL/c nude colorectal cancer (CRC) model Dosage:5-10 mg/kg Administration:Intraperitoneal injection; 5-10 mg/kg; 5 d/wk; 4 weeks Result:Displayed lower cell proliferation indices and higher cell apoptosis.Exhibited no statistically significant weight loss or other signs of acute or delayed toxicity in mice.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMTHFD1
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Research Area——
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Indication——
Chemical Information
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CAS Number10538-99-5
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Formula Weight471.42
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Molecular FormulaC20H21N7O7
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Purity>98% (HPLC)
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SolubilityDMSO:125 mg/mL (265.16 mM; Need ultrasonic)
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SMILESNc1nc(=O)c2N3C(CN(C3=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.
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