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LY 345899

CAS No. 10538-99-5

LY 345899 ( —— )

Catalog No. M22500 CAS No. 10538-99-5

LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    LY 345899
  • Note
    Research use only, not for human use.
  • Brief Description
    LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
  • Description
    LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    MTHFD1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    10538-99-5
  • Formula Weight
    471.42
  • Molecular Formula
    C20H21N7O7
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:125 mg/mL (265.16 mM; Need ultrasonic)
  • SMILES
    Nc1nc(=O)c2N3C(CN(C3=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2[nH]1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Schmidt A, et al. Structures of three inhibitor complexes provide insight into the reaction mechanism of the human methylenetetrahydrofolate dehydrogenase/cyclohydrolase. Biochemistry. 2000 May 30;39(21):6325-35.
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